发明名称 |
C2-C5-ALKYL-IMIDAZOLE-BISPHOSPHONATES |
摘要 |
<p>C2-C5-Alkyl-substituted [(imidazol-1 -yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acids, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, methods of using them in the treatment of diseases, pharmaceutical formulations encompassing them and/or the compounds for use in the treatment of diseases, are described. The compounds are able to inhibit excessive or inappropriate bone resorption and for the treatment of other diseases which are caused by excessive prenylation of target proteins, such as Hutchinson-Gilford progeria syndrome. The compounds are of the formula (I), wherein one of R1 and R2 is hydrogen and the other is C2-C5-alkyl that is branched or unbranched, and can be in free form, in the form of an ester, and/or of a salt.</p> |
申请公布号 |
WO2009068567(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
WO2008EP66245 |
申请日期 |
2008.11.26 |
申请人 |
NOVARTIS AG;WEILER, SVEN;WIDLER, LEO;RONDEAU, JEAN-MICHEL;COTESTA, SIMONA;JAHNKE, WOLFGANG |
发明人 |
WEILER, SVEN;WIDLER, LEO;RONDEAU, JEAN-MICHEL;COTESTA, SIMONA;JAHNKE, WOLFGANG |
分类号 |
C07F9/6506;A61K31/663;A61P19/00 |
主分类号 |
C07F9/6506 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|