发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVATION OF DSRNA-DEPENDENT PROTEIN KINASE AND TUMOR GROWTH INHIBITION |
摘要 |
The present invention relates to compositions and methods for preventing and treating a condition in a mammalian subject that include at least one inhibitor of double stranded RNA dependent protein kinase (PKR-I) prior to or concurrently with the treatment, wherein the treatment results to an inhibition of activation of dsRNA-dependent protein kinase. The compositions and methods of the present invention further include at least one potentiator that further enhances the inhibition of phosphorylation by PKR-I. |
申请公布号 |
CA2706656(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
CA20082706656 |
申请日期 |
2008.10.03 |
申请人 |
NESTEC S.A. |
发明人 |
TISDALE, MICHAEL JOHN;ELEY, HELEN LAURA;RUSSELL, STEVE THOMAS;MILLER, KEVIN BURKE |
分类号 |
A61K31/429;A23L1/305;A61K31/198;A61K31/52;A61K31/553;A61K45/06;A61P1/14;A61P3/10;A61P9/04;A61P17/00;A61P19/02;A61P25/28;A61P29/00;A61P31/18;A61P35/00 |
主分类号 |
A61K31/429 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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