发明名称 |
14-3-3 ANTAGONISTS FOR THE PREVENTION AND TREATMENT OF ARTHRITIS |
摘要 |
Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14- 3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3. |
申请公布号 |
CA2706479(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
CA20082706479 |
申请日期 |
2008.11.26 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
MAROTTA, ANTHONY;GHAHARY, AZIZ;MAKSYMOWYCH, WALTER WOLODYMYR PETER;KILANI, RUHANGIZ |
分类号 |
A61K39/395;A61K38/08;A61K45/00;A61P19/02;C07K16/18;C12N5/16 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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