NEW ACTIVATOR OF ORPHAN RECEPTOR IN NUCLEUS AND APPLICATION OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a new activator of an orphan receptor in a nucleus, useful as a therapeutic agent of liver diseases, metabolic disorders, etc. SOLUTION: This compound expressed by general formula (I) [R1is cyclohexyl, a phenyl having≥1 substituent, a thienyl having≥1 substituent, a furyl having≥1 substituent, thiazolyl, phenoxy, a 7-9C phenylalkyl; phenylthio, morphorino, piperidyl, pyrrolidinyl, pyridyl or imidazolyl; R2is -CHR3R4or cyclohexyl; and ring A is a benzene ring, thiophene ring or furan ring], its pharmaceutically acceptable salt or its solvated material is used as a pregnane receptor activator. COPYRIGHT: (C)2009,JPO&INPIT