NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT
摘要
In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a novel carrier for CEST contrast agents is provided. The carrier is non-spherical and comprises a semipermeable shell, wherein the shell comprises a paramagnetic compound. The shell encloses a cavitycomprising an MR analyte, wherein the semipermeable shell allows diffusion of the MR analyte. The CEST effect is based on the 5 bulk magnetic susceptibility effect caused by the anisotropy of the carrier. This leads to a versatile carrier that does not require interaction of the analyte with a paramgnetic chemical shift reagent.
申请公布号
WO2009069051(A2)
申请公布日期
2009.06.04
申请号
WO2008IB54894
申请日期
2008.11.21
申请人
KONINKLIJKE PHILIPS ELECTRONICS N.V.;BURDINSKI, DIRK;LANGEREIS, SANDER;PIKKEMAAT, JEROEN, A.
发明人
BURDINSKI, DIRK;LANGEREIS, SANDER;PIKKEMAAT, JEROEN, A.