发明名称 |
2, 6-DISUBSTITUTED PYRIDINES AND 2, 4-DISUBSTITUTED PYRIMIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS |
摘要 |
<p>Disclosed are compounds of formula (I): wherein n represents 1 or 2; each R1 independently represents halo or trifluoromethyl; wherein halo represents fluoro, chloro or bromo; R2 represents hydrogen or C1-3alkyl; X represents N or CH; wherein -Z- represents a group selected from: (A), (B) or (C), wherein R3 represents trifluoromethyl or C1-3alkyl; and R4 represents hydrogen, trifluoromethyl or C1-3alkyl; with the proviso that where Z represents a thiophene group and X represents N, R2 cannot represent C1-3alkyl; and when X represents CH, -Z- can additionally represent a group selected from: (D) or (E) or salts thereof which activate soluble guanylate cyclase (sGC) pharmaceutical compositions containing them, their use is medicine, and processes for their preparation.</p> |
申请公布号 |
WO2009068652(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
WO2008EP66444 |
申请日期 |
2008.11.28 |
申请人 |
SMITHKLINE BEECHAM CORPORATION;BOYER, THIERRY;DODIC, NERINA;EVANS, BRIAN;KIRK, BARRIE EDWARD |
发明人 |
BOYER, THIERRY;DODIC, NERINA;EVANS, BRIAN;KIRK, BARRIE EDWARD |
分类号 |
C07D401/04;A61K31/4436;A61K31/4439;C07D213/643;C07D403/04;C07D409/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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