PERIPHERAL NERVOUS SYSTEM-SPECIFIC SODIUM CHANNEL, DNA ENCODING THE SAME, CRYSTALLIZATION, X-RAY DIFFRACTION, COMPUTER MOLECULAR MODELING, RATIONAL DRUG DESIGN, DRUG SCREENING, METHOD FOR PRODUCING THE SAME, AND METHOD FOR USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a diagnosis and/or a treatment of pathologies related to impaired PNS (peripheral nervous system) nerve conduction.

SOLUTION: There provided are cloning, expression, viral and delivery vectors, and hosts which contain a nucleic acid encoding at least one PNS SCP (sodium channel peptide), isolated PNS SCP, and compounds, and compositions, and methods for isolating, crystallizing, X-ray analyzing molecular modeling, rational drug designing, selecting, producing and using therapeutic agents or diagnostic agents, or ligands having at least one PNS SC (sodium channel) modulating activity.

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