SALICYLANILIDE MODIFIED PEPTIDES FOR USE AS ORAL THERAPEUTICS
摘要
This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that shows higher bioactivity when orally administered than the unmodified peptide.
申请公布号
WO2009032749(A3)
申请公布日期
2009.06.04
申请号
WO2008US74624
申请日期
2008.08.28
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNINA;FOGELMAN, ALAN, M.;NAVAB, MOHAMAD