| 摘要 |
Double-stranded oligonucleotides useful as decoy oligonucleotides having a high binding ability to a transcription factor and having a reduced cytotoxicity are disclosed. Each of the double-stranded oligonucleotides is formed by hybridization of a sense strand oligonucleotide of the following Formula A: <?in-line-formulae description="In-line Formulae" end="lead"?>5'-N(m)-G-Consensus Sequence-C-N(n)-3' (Formula A)<?in-line-formulae description="In-line Formulae" end="tail"?> (wherein N(m) is a flanking sequence at the 5'-end, and represents that "N" (s) in the number of m is(are) ligated; N(n) is a flanking sequence at the 3'-end, and represents that "N" (s) in the number of m is(are) ligated; all "N" (s) each independently represent(s) nucleotide A, G, T, C or U; m and n represent each independently an integer of 0 to 20; and Consensus Sequence represents a consensus sequence to which a transcription factor binds) and an antisense strand oligonucleotide complementary to said sense strand oligonucleotide.
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