| 摘要 |
The present invention is directed to progesterone-containing compositions and devices that can maintain opening of a body passageway. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, and/or anti -thrombotic) composition or formulation containing progesterone and optionally vitamin E. Another aspect of the invention provides a drug eluting device with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices. |
