发明名称 |
Method for Cleaving Cervimycin Monoesters |
摘要 |
The invention relates to a method for cleaving cervimycin esters. An object of the invention to convert in a simple manner the cervimycin esters which are less active but formed in larger quantity into the highly active cervimycin K that occurs as a minor component in the preparation by fermentation, is achieved by preparing unesterified cervimycins from cervimycin esters with di- or monomethylated malonic acids, by ester cleavage effected by at least one esterolytic enzyme at temperatures of 20° C. to 75° C. and a pH of pH 5.0 to 10.0, preferably pH 6.0 to 9.0.
|
申请公布号 |
US2009142809(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
US20060084721 |
申请日期 |
2006.09.25 |
申请人 |
LEIBNIZ-INSTITUT FUER NATURSTOFF-FORSCHUNG UND INFE;FRIEDRICH-SCHILLER-UNIVERSITAET JENA |
发明人 |
HORN UWE;SIERING ARMIN;PESCHEL GUNDELA;HERTWECK CHRISTIAN;MULLER PETER-JURGEN;BARDL BETTINA;OZEGOWSKI JORG-HERMANN;HEROLD KERSTIN |
分类号 |
C12P19/56 |
主分类号 |
C12P19/56 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|