NUCLEOTIDE SEQUENCE ENCODING ARTEMISINIC ALDEHYDE DOUBLE BOND REDUCTASE, ARTEMISINIC ALDEHYDE DOUBLE BOND REDUCTASE AND USES THEREOF

摘要

An isolated nucleic acid molecule cloned from Artemisia annua encodes an artemisinic aldehyde double bond reductase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to (11R)-dihydroartemisinic aldehyde. The nucleic acid molecule, and the enzyme encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde and/or dihydroartemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the antimalarial compound artemisinin.