发明名称 |
NOVEL USE OF A POLYAMINE-POOR COMPOSITION FOR THE PRODUCTION OF A MEDICAL HUMAN FOOD |
摘要 |
The use of a human food composition (A) containing less than 1600 picomoles per g of polyamines (I) is claimed in the production of a therapeutic food for combating syndromes or disorders involving the NR2-N subunit of the N-methyl-D-aspartate (NMDA) receptor. ACTIVITY : Analgesic; Vasotropic; Neuroprotective; Nootropic; Antiparkinsonian; Anticonvulsant; Virucide; Antimanic; Antidepressant; Neuroleptic; Antiaddictive; Auditory. In tests in rats fed (a) a solid diet with a very low polyamine (I) content of less than 10 mu g/kg or (b) the same diet supplemented with the polyamines putrescine (54 mg/kg), spermine (7 mg/kg) and spermidine (7 mg/kg) (i.e. the levels present in normal rodent feed), the sensitivity to pain caused by two injections (7 days apart) of carrageenan into the paw was measured by the Randall-Selitto test. The level of pain in the days following the second injection was markedly lower in group (a) than that in group (b), demonstrating that the low-(I) diet in group (a) reduced the sensitivity to pain. The levels of pain in the days following the first injection were not significantly different, demonstrating the low-(I) diet had no direct analgesic effect. MECHANISM OF ACTION : NMDA receptor NR2-N subunit modulator. |
申请公布号 |
EP1648431(B1) |
申请公布日期 |
2009.06.03 |
申请号 |
EP20040767761 |
申请日期 |
2004.07.22 |
申请人 |
UNIVERSITE DE RENNES 1;UNIVERSITE VICTOR SEGALEN BORDEAUX II |
发明人 |
MOULINOUX, JACQUES-PHILIPPE;SIMONNET, GUY |
分类号 |
A61K31/132;A23L1/29;A23L1/305;A61P9/10;A61P25/00;A61P31/12 |
主分类号 |
A61K31/132 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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