发明名称 |
ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION |
摘要 |
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. |
申请公布号 |
EP2064334(A2) |
申请公布日期 |
2009.06.03 |
申请号 |
EP20070838549 |
申请日期 |
2007.09.19 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARRICO, ISAAC S.;CARLSON, BRIAN L.;BERTOZZI, CAROLYN;WU, PENG |
分类号 |
C07K1/00;C07K1/107;C07K1/13;C07K16/46;C12P21/00 |
主分类号 |
C07K1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|