发明名称 |
Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors |
摘要 |
Methods and compositions relating to recombinant anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells.
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申请公布号 |
US7541034(B1) |
申请公布日期 |
2009.06.02 |
申请号 |
US19980381497 |
申请日期 |
1998.03.19 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
FITZGERALD DAVID J.;PASTAN IRA;MANSFIELD ELIZABETH;KREITMAN ROBERT |
分类号 |
A61K39/00;G01N33/53;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K48/00;A61P35/00;C07K16/28;C07K19/00;C12N1/21;C12N15/09;G01N33/574 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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