发明名称 |
PROPOFOL FORMULATION WITH ENHANCED MICROBIAL CHARACTERISTICS |
摘要 |
Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduce s the chances of fat overload when administered over an extended period of time to chronically ill patients.
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申请公布号 |
CA2366793(C) |
申请公布日期 |
2009.06.02 |
申请号 |
CA20002366793 |
申请日期 |
2000.03.29 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
DELA ROSA, JOSBEN C.;RABINOW, BARRETT E.;MOTHERAM, RAJESHWAR;PEJAVER, SATISH K. |
分类号 |
A61K31/05;A61K9/107;A61K47/10;A61K47/24;A61K47/44;A61K47/46;A61P23/00 |
主分类号 |
A61K31/05 |
代理机构 |
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代理人 |
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地址 |
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