发明名称 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain |
摘要 |
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live vaccine for immunization, prophylaxis or treatment of brucellosis comprises such a bacterium, either lyophilized or in a pharmaceutical vehicle. Nucleotide sequence fragments having the aforementioned deletion are disclosed, with methods for making them.
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申请公布号 |
US7541447(B2) |
申请公布日期 |
2009.06.02 |
申请号 |
US20040978244 |
申请日期 |
2004.10.28 |
申请人 |
UGALDE JUAN ESTEBAN;COMERCI DIEGO JOSE;UGALDE RODOLFO AUGUSTO;DEL VECCHIO VITO G |
发明人 |
UGALDE JUAN ESTEBAN;COMERCI DIEGO JOSE;UGALDE RODOLFO AUGUSTO;DEL VECCHIO VITO G. |
分类号 |
C07H21/02;A01N63/00;A61K49/00;C07H21/04 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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