| 发明名称 |
PROCESS FOR THE PREPARATION OF 5-ARYLNICOTINALDEHYDES |
| 摘要 |
The invention relates to a process for the preparation of 5-arylnicotin-aidehydes by reduction of the corresponding 5-aryinicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.
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| 申请公布号 |
CA2399125(C) |
申请公布日期 |
2009.06.02 |
| 申请号 |
CA20012399125 |
申请日期 |
2001.01.05 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
KNIERIEMEN, RALF;MURMANN, CHRISTOPH;BATHE, ANDREAS;BOKEL, HEINZ;KEIL, THOMAS |
| 分类号 |
C07D213/48;C07D213/78;C07D213/30;C07D213/80;C07D213/803;C07D401/04;C07D405/12 |
主分类号 |
C07D213/48 |
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