发明名称 |
Adhesin-enterotoxin chimera based immunongenic composition against enterotoxigenic Escherichia Coli |
摘要 |
The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
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申请公布号 |
US2009136567(A1) |
申请公布日期 |
2009.05.28 |
申请号 |
US20070988598 |
申请日期 |
2007.01.11 |
申请人 |
SAVARINO STEPHEN J;HOLMES RANDALL K;JOBLING MICHAEL G |
发明人 |
SAVARINO STEPHEN J.;HOLMES RANDALL K.;JOBLING MICHAEL G. |
分类号 |
A61K9/48;A61K35/74;A61K39/108;C07K14/245 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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