| 发明名称 |
CANCER DIAGNOSTIC AND THERAPEUTIC METHODS THAT TARGET PLK4/SAK |
| 摘要 |
<p>Methods of assessing expression of PLK4 in a cancer patient for use in determining if the patient is a candidate for PLK4antagomst therapy, predicting cancer metastasis and if the patient is a candidate for aggressive cancer therapy. Also provided is the use of PLK4 antagonists in the treatment of cancer and metastasis. Preferred cancers for treatment are breast cancer (basal sub-type and luminal B sub-type) and soft tissue cancers.</p> |
| 申请公布号 |
WO2009065232(A1) |
申请公布日期 |
2009.05.28 |
| 申请号 |
WO2008CA02087 |
申请日期 |
2008.11.20 |
| 申请人 |
UNIVERSITY HEALTH NETWORK;PAN, GUOHUA |
发明人 |
PAN, GUOHUA |
| 分类号 |
A61K31/553;A61K31/404;A61K31/427;A61K31/437;A61K31/44;A61K31/4439;A61K31/506;A61K31/519;A61K31/551;A61K31/7105;A61K48/00;A61P35/00;A61P35/04;G01N33/573;G01N33/574;G01N33/68 |
主分类号 |
A61K31/553 |
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