发明名称 |
STREPTOCOCCUS PNEUMONIAE PILUS ANTIGENS |
摘要 |
Polypeptides from Streptococcus pneumoniae are described. In some aspects the polypeptides include pili polypeptides from a second pili island (pilus II island (INVl 04B)) identified in Streptococcus pneumoniae isolate INVl 04. In other aspects the polypeptides include pili polypeptides and non-pilus polypeptides from Streptococcus pneumoniae strains 23F, INV200, and OXC141 that are absent from Streptococcus pneumoniae isolate INV104. The polypeptides, including fragments and variants thereof, may be used in immunogenic compositions for prophylactic or therapeutic immunization against Streptococcus pneumoniae. The polypeptides are also disclosed to be used in compositions useful for the production of antibodies and immunostimulants. Also presented are methods of inhibiting Streptococcus pneumoniae, methods of treating Streptococcus pneumoniae infection, methods of identifying inhibitors of Streptococcus pneumoniae and methods for diagnosing/detecting Streptococcus pneumoniae infection. |
申请公布号 |
WO2008146164(A3) |
申请公布日期 |
2009.05.28 |
申请号 |
WO2008IB02108 |
申请日期 |
2008.05.23 |
申请人 |
NOVARTIS AG;DONATI, CLAUDIO;MASIGNANI, VEGA;MORA, MARIROSA;MOSCHIONI, MONICA |
发明人 |
DONATI, CLAUDIO;MASIGNANI, VEGA;MORA, MARIROSA;MOSCHIONI, MONICA |
分类号 |
C07K14/315;A61K39/09;C07K16/12;C12N9/10;G01N33/569 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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