BONE MORPHOGENIC PROTEIN BINDING PEPTIDE

摘要

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all ostcogenic activity of rhBMP- 2, increases the rate at which rhBMP-2 induces bone formation, and BBP in-duces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diag-nostic and clinical applications requiring calcification and ostcogcnesis.