摘要 |
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H- pyrido[2,3-d]pyrimidine-7-one (1) a MAP -kinase inhibitor useful in the treatment of rheumatoid arthritis. |
申请人 |
F. HOFFMANN-LA ROCHE AG;CLEARY, THOMAS, P.;JI, YAOHUI;LEE, GARY, R.;RAWALPALLY, THIMMA;SARMA, KESHAB |
发明人 |
CLEARY, THOMAS, P.;JI, YAOHUI;LEE, GARY, R.;RAWALPALLY, THIMMA;SARMA, KESHAB |