发明名称 |
SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS |
摘要 |
<p>The invention relates to substituted benzothiazoles, benzoxazoles - and their counterparts having pyridine and pyrimidine rings replacing the benzene ring - that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula (I), in which A and B are carbocycles or heterocycles. A particular embodiment is Formula (II).</p> |
申请公布号 |
WO2009067618(A1) |
申请公布日期 |
2009.05.28 |
申请号 |
WO2008US84225 |
申请日期 |
2008.11.20 |
申请人 |
DECODE GENETICS EHF;SINGH, JASBIR;GURNEY, MARK;BURGIN, ALEX;KISELYOV, ALEXANDER;RAO, MUNAGALA |
发明人 |
SINGH, JASBIR;GURNEY, MARK;BURGIN, ALEX;KISELYOV, ALEXANDER;RAO, MUNAGALA |
分类号 |
C07D263/56;A61K31/423;A61K31/428;A61K31/4439;A61K31/519;A61P29/00;C07D263/58;C07D277/62;C07D277/82;C07D417/04;C07D417/06;C07D417/14;C07D513/04 |
主分类号 |
C07D263/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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