发明名称 |
Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations |
摘要 |
Nanoparticulate compositions comprising a corticosteroid and a leukotriene receptor antagonist are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining a leukotriene receptor antagonist with a corticosteroid in a particle size ranges of less than 2000 nm in a single formulation results in improved efficacy. In addition, patient compliance is enhanced since only one dosage form is needed. Furthermore, local administration of the leukotriene receptor antagonist results in less liver toxicity since the liver will be exposed to lower amounts of drug than happens following oral administration. The drug compositions according to the invention can be formulated into inhalation, nasal, or ocular formulations. |
申请公布号 |
ZA200708456(B) |
申请公布日期 |
2009.05.27 |
申请号 |
ZA20070008456 |
申请日期 |
2007.10.03 |
申请人 |
ELAN PHARMA INTERNATIONAL LIMITED |
发明人 |
LIVERSIDGE, GARY;WERTZ, CHRISTIAN;JENKINS, SCOTT;BOSCH, H. |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|