发明名称 |
SUBSTITUTED AZEPINO[4,3-B]INDOLES, PHARMACOLOGICAL COMPOSITION AND A METHOD FOR THE PRODUCTION AND USE THEREOF |
摘要 |
The invention relates to novel chemical compounds, searching for novel physiologically active substanses, leader compounds, "molecular tools", and drug candidates obtained on the basis of screening of combinatorial and focused libraries of the said compounds, and also to pharmaceutical composition, methods for preparation and use thereof. The invention proposes hydrogenated azepino[4,3-b]indoles of general formula 1 or racemates, optical isomers, geometrical isomers, mixtures of optical or geometrical isomers, pharmaceutically acceptable salts and/or hydrates thereof:
wherein: solid line together with the dotted line ( --- ) represents a single or double bond; R 1 and R 2 independently of each other are amino group substituents selected from hydrogen; optionally substituted C 1 -C 8 alkyl with substituents selected from optionally substituted aryl or 5-6-membered azaheterocyclyl; C 1 -C 8 alkoxycarbonyl; optionally substituted phenyl; optionally substituted carbonylamino or thiocarbonylamino; substituted acyl; C 1 -C 8 alkylsulfonyl; optionally substituted arylsulfonyl; upon that, the substituents in the said R 1 and R 2 independently selected from C 1 -C 8 alkyl, halogen atoms, nitro group, carboxy group, alkoxy, aryl; R i n represents one or more "substituents of cyclic structure" of the same or different structure selected from hydrogen, halogen, C 1 -C 8 alkyl, C 6 -C 10 aryl, 5-6-membered azaheterocyclyl.
|
申请公布号 |
EP2062895(A1) |
申请公布日期 |
2009.05.27 |
申请号 |
EP20070834964 |
申请日期 |
2007.08.08 |
申请人 |
ALLA CHEM, LLC.;IVASHCHENKO, ANDREY, ALEXANDROVICH |
发明人 |
IVASHCHENKO, ANDREY ALEXANDROVICH;FROLOV, YEVGENIY BORISOVICH;TKACHENKO, SERGEY YEVGENIEVICH;KHVAT, ALEXANDER VIKTOROVICH;MALYARCHUK, SERGEY VIKTOROVICH;MITKIN, OLEG DMITRIEVICH;OKUN, ILYA MATUSOVICH;KYSELEV, ALEXANDR SERGEEVICH;SAVCHUK, NIKOLAY FILIPPOVICH;IVASHCHENKO, ALEXANDR VASILIEVICH |
分类号 |
C07D487/04;A61K31/55;A61P3/14;A61P9/10;A61P17/00;A61P17/02;A61P17/06;A61P25/08;A61P25/14;A61P25/28 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|