发明名称 BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCATORS
摘要 FIELD: pharmacology. ^ SUBSTANCE: described are novel derivatives of triazole of general formulas (I) or (II) or their pharmaceutically acceptable salts, where R1 represents H, C1-C6-alkyl, or group CONRaRb, Ra represents hydrogen or C1-C6-alkyl; R2 represents H or C1-C6-alkyl; R3 represents H or F, CI, Br or I; R4 represents H; R5 represents CF3 or O-(C1-C4)alkyl, three times substituted with F; R6 and R7 each independently represents H, F or CF3, on condition that one of R6 and R7 always represents H. ^ EFFECT: application of said compounds for preparing medication for treatment and prevention of pain or pain-induced disturbances; pharmaceutical composition containing novel compounds, and method of their obtaining. ^ 9 cl, 20 ex
申请公布号 RU2356897(C2) 申请公布日期 2009.05.27
申请号 RU20050132168 申请日期 2004.03.12
申请人 MERK EHND KO. INK. 发明人 CHAKRAVARTI PRASUN K.;FISHER MAJKL KH.;PALUKI BRENDA;PARK MIN K.;PARSONZ UIL'JAM KH.;CHZHOU BISHAN';KEHRI DZHEJMS P.;FRANTS DUGLAS EH.;KRESS MAJKL KH.;UIVER DEJMIAN
分类号 A61K31/4196;A61P25/00;C07D249/08;C07D249/10 主分类号 A61K31/4196
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