发明名称 |
Compositions of lipoxygenase inhibitors |
摘要 |
Pharmaceutical compositions comprising particles of lipoxygenase inhibitor compounds having an effective average size of from about 10 nm to about 50 microns are provided. More particularly, pharmaceutical compositions of particle of a 5-lipoxygenase inhibitor compound having an effective average size of from about 50 nm to about 5 microns are provided. The pharmaceutical compositions are in the form of aqueous suspensions with the particle of the 5-lipoxygenase inhibitor compound present in concentrations of from about 5 to about 200 mg/ml. In addition, methods for making such pharmaceutical compositions are provided. In particular, microprecipitation and direct homogenization in the presence of at least one surfactant are disclosed for making the pharmaceutical compositions. |
申请公布号 |
ZA200805000(B) |
申请公布日期 |
2009.05.27 |
申请号 |
ZA20080005000 |
申请日期 |
2008.06.09 |
申请人 |
BAXTER INTERNATIONAL, INC.;BAXTER HEALTHCARE SA. |
发明人 |
KIPP, JAMES E.;WERLING, JANE;GUPTA, PRAMOD;BURESH, RITA |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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