发明名称 |
PROCESS FOR THE PREPARATION OF 4-HYDROXYALKYLAMINO-2-NITRO-ANISOLES |
摘要 |
A process for the preparation of 4-hydroxyalkylamino-2-nitro-anisoles of the general formula (I) wherein m is 2 or 3; by reaction of a 4-halogeno-3-nitro-aniline of formula (II) with a chloroalkyl-chloroformate, alkaline ring closure of the resulting carbamate and nucleophilic replacement of the halogeno atom by a methoxy group to form a derivative of formula (IV), and finally ring opening of the resulting cyclic carbamate by treatment with methanolic alkali metal hydroxide, followed by neutralization with inorganic or organic acids, wherein the complete reaction is executed in a non-aqueous medium; as well as process for the preparation of 2-amino-4- hydroxyalkylamino-anisoles of formula (V). |
申请公布号 |
WO2007122579(A3) |
申请公布日期 |
2009.05.22 |
申请号 |
WO2007IB51468 |
申请日期 |
2007.04.20 |
申请人 |
THE PROCTER & GAMBLE COMPANY;WELLA AKTIENGESELLSCHAFT;GOETTEL, OTTO;MORAND, EMMANUEL;BRAUN, HANS-JUERGEN |
发明人 |
GOETTEL, OTTO;MORAND, EMMANUEL;BRAUN, HANS-JUERGEN |
分类号 |
C07C213/00;C07C217/84 |
主分类号 |
C07C213/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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