METHODS OF DETECTION AND ENRICHMENT OF PRPSC BY IMMUNOPRECIPITATION AND ELISA

摘要

The invention relates to a method of extracting or enriching PrP sc from a sample, said method comprising: (i) contacting said sample with a reagent which selectively binds PrPsc (ii) incubating said reagent with said sample (iii) separating or concentrating said reagent from said sample wherein said reagent comprises an ICSM33 antibody or a fragment or fusion thereof. The invention also relates to methods of detection of PrPsc, and to buffers and materials for use in same.