摘要 |
<p>The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.</p> |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;KAHNE, DANIEL;WALKER, SUZANNE;ADACHI, MASAATSU;DOUD, EMMA;FUSE, SHINICHIRO;LIN, XIAONAN;ZHANG, YI;TSUKAMOTO, HIROKAZU;OSTASH, BOHDAN |
发明人 |
KAHNE, DANIEL;WALKER, SUZANNE;ADACHI, MASAATSU;DOUD, EMMA;FUSE, SHINICHIRO;LIN, XIAONAN;ZHANG, YI;TSUKAMOTO, HIROKAZU;OSTASH, BOHDAN |