发明名称 |
COMPOSITIONS AND METHOD FOR MANIPULATING PIM-1 ACTIVITY IN CIRCULATORY SYSTEM CELLS |
摘要 |
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase PIM-I, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding PIM-I, and methods for enhancing the regenerative potential of stem cells in the heart. |
申请公布号 |
CA2705862(A1) |
申请公布日期 |
2009.05.22 |
申请号 |
CA20082705862 |
申请日期 |
2008.11.14 |
申请人 |
SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
MURASKI, JOHN A., JR.;SUSSMAN, MARK A. |
分类号 |
A61K38/45;A61K35/12;A61K35/44;A61K48/00;A61P9/00;C12N5/0775;C12N5/10;C12N9/12;C12N15/00;C12N15/54;C12N15/85;C12Q1/48 |
主分类号 |
A61K38/45 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|