NOVEL RESOLUTION PROCESS FOR PREGABALIN

摘要

Present invention relates to a novel and improved process for the resolution of racemic pregabalin of formula (I) into (S)-(+)-pregabalin [(S)-(+)-3-aminomethyl-5-methylhexanoic acid] of formula (III) via the novel acid addition salt [(S)-(+) 3-aminomethyl-5-methylhexanoic acid, (-)-O, O'-di-p-toluoyl-L-tartaric acid salt] of formula (II). (S)-(+)-pregabalin of formula-III has analgesic, anticonvulsant and anxiolytic properties and hence is of great therapeutic significance.