发明名称 |
BIOMARKERS AND METHODS FOR DIAGNOSING, PREDICTING AND/OR PROGNOSING SEPSIS AND USES THEREOF |
摘要 |
<p>The present invention provides kits and methods for the diagnosis, prognosis and prediction of sepsis in a subject or for the differentiation between sepsis and SIRS in a subject, the method comprising(a) measuring the level of pro-hepcidin (pro-HEPC) in a biological sample taken from said subject, (b) measuring the level of at least one further biomarker selected from the group consisting of soluble TNF-receptor 2 (sTNFR2), Pentraxin-3 (PTX-3), Macrophage Colony-Stimulating Factor (MCSF), pro-Brain Natriuretic Protein (pro-BNP), one or more members of the Histone protein family, Procalcitonin (PCT) and c-Reactive Protein (CRP) in a biological sample from said subject, (c) using said measurements obtained in steps (a) and (b) to create a profile for said biomarkers and (d) comparing said profile with a reference biomarker profile obtained form a patient having SIRS or from a healthy subject.</p> |
申请公布号 |
WO2009062948(A1) |
申请公布日期 |
2009.05.22 |
申请号 |
WO2008EP65364 |
申请日期 |
2008.11.12 |
申请人 |
PRONOTA N.V.;KAS, KOEN;VANPOUCKE, GRIET;DEGROEVE, SVEN;HUIJBEN, KATHLEEN |
发明人 |
KAS, KOEN;VANPOUCKE, GRIET;DEGROEVE, SVEN;HUIJBEN, KATHLEEN |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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