Fcepsilon-PE (FC EPSILON PSEUDOMONAS EXOTOXIN) CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSE, METHOD FOR ITS PRODUCTION, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a new approach for the therapy of allergic responses.

SOLUTION: The chimeric protein comprises a cell targeting moiety for FcεRI expression cells, preferably, Fc site of a mouse IgE molecule and a cell killing moiety. Preferably, the chimeric protein contains a bacterial toxin Pseudomonas exotoxin (PE). The chimeric protein specifically and efficiently kills mouse mast cell lines expressing the FcεRI receptor, as well as primary mast cells derived from bone marrow. The pharmaceutical composition for the treatment of allergic diseases and for the treatment of hyperplasia and malignant tumor utilizes the chimeric protein.

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