发明名称 |
PAI-1 BINDING MODULATORS FOR THE TREATMENT OF OCULAR DISORDERS. |
摘要 |
<p>The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 binding to vitronectin. In another embodiment, the invention concerns a method of manufacturing a compound to be used as a treatment for glaucoma or elevated IOP comprising providing a candidate substance suspected of modulating PAI-1 binding, selecting the compound by assessing the ability of the candidate substance to decrease the amount of active PAI-1 in the trabecular meshwork of a subject suffering from glaucoma or elevated PAI-1, and manufacturing the selected compound.</p> |
申请公布号 |
MX2009004792(A) |
申请公布日期 |
2009.05.21 |
申请号 |
MX20090004792 |
申请日期 |
2007.10.31 |
申请人 |
ALCON RESEARCH, LTD. |
发明人 |
PANG, IOK-HOU;FLEENOR, DEBRA;CLARK, ABBOT |
分类号 |
A61K31/122;A61K31/19;A61K31/41;A61P35/00 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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