| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention concerns novel pyrazole derivatives of the formula (IIIa) , where R1 is T-(ring D), where ring D is naphthyl or phenyl optionally substituted by -R5; Rx, Ry, R2, R2' and R5 are as defined in the claim; and pharmaceutical composition containing claimed compounds. Compounds inhibit protein kinases such as Aurora-2, GSK-3 or Src and can be applied in treatment methods for diseases mediated by the indicated protein kinases, such as cancer, diabetes and Alzheimer's disease. ^ EFFECT: compounds also applicable in methods of hyperphosphorylated protein Tau products inhibition and -catenin phosphorylation inhibition. ^ 24 cl, 12 tbl, 292 ex |
