ANTI-TUMOR COMPOSITIONS CONTAINING RAPAMICINE DERIVATIVE AND AROMATASE INHIBITOR

摘要

FIELD: medicine; oncology. ^ SUBSTANCE: in treatment of breast cancer in mammal introduction of rapamicine esters with aromatase inhibitor in form of combination o in pharmaceutical composition is realised. As rapamicine esters CCI-779 or 42-O-(2-hdroxy)ethylrapamicine is introduced, as aromatase inhibitor - letrozole in subtherapeutic doses. ^ EFFECT: enhancing anti-tumor effect due to synergetic effect resulting from combination of definite rapamicine ester with particular aromatase inhibitor. ^ 7 cl, 2 ex