Medical compositions for intravesical treatment of bladder cancer

摘要

An anti-cancer formulation comprising: 5-(1-azaridinyl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methyl-1H-indole-4,7-dione (EO9) and a buffered formulation vehicle comprising tert-butanol/water. There is also discloses a method of preparing a formulation comprising 5-(1-azaridinyl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methyl-1H-indole-4,7-dione (EO9), which method comprises preparing a formulation comprising 5-(1-azaridinyl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methyl-1H-indole-4,7-dione (EO9) and a buffered formulation vehicle comprising tert-butanol/water, and lyophilising the formulation to give a lyophilisate.