发明名称 |
USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN |
摘要 |
Polyols stabilize polymorphous form of rifaximin, in particular the &bgr; form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph &bgr; is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described. |
申请公布号 |
EP2059232(A1) |
申请公布日期 |
2009.05.20 |
申请号 |
EP20070804680 |
申请日期 |
2007.07.31 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
MAFFEI, PAOLA;BACHETTI, MILENA;BOTTONI, GIUSEPPE;VISCOMI, GIUSEPPE, CLAUDIO |
分类号 |
A61K9/16;A61K9/20;A61K9/28;A61K9/50;A61K31/437;A61K47/10;A61K47/26;A61K47/36;A61K47/38 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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