| 发明名称 |
Mammalian artificial chromosomes |
| 摘要 |
A mammalian chromosome is produced according to the method comprising the steps of:
introducing a DNA construct comprising a mammalian telomere and a centromere into a mammalian cell, wherein the centromere has a DNA sequence containing some copies of CENP-B box sequence consisting of:
5'-NTTCGNNNNANNCGGGN-3'
wherein N is any one of A, T, C and G.
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| 申请公布号 |
EP2060633(A1) |
申请公布日期 |
2009.05.20 |
| 申请号 |
EP20080013992 |
申请日期 |
1996.08.26 |
| 申请人 |
CHROMO RESEARCH, INC. |
发明人 |
OKAZAKI, TSUNEKO;MASUMOTO, HIROSHI;MASASHI, IKENO;HOWARD, COOKE;GRIMES, BRENDA, ROSE |
| 分类号 |
C12N15/09;C12N15/85;A61K48/00;C07H21/04;C12N1/19;C12N5/06;C12N5/08;C12N5/10;C12N9/22;C12N15/81;C12P21/02 |
主分类号 |
C12N15/09 |
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