发明名称 |
DNA VACCINATION FOR INDUCTION OF SUPPRESSIVE T CELL RESPONSE |
摘要 |
A pro-inflammatory T response is specifically prevented by the injection int o a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.
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申请公布号 |
CA2247071(C) |
申请公布日期 |
2009.05.19 |
申请号 |
CA19972247071 |
申请日期 |
1997.02.24 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
STEINMAN, LAWRENCE;WAISMAN, ARI |
分类号 |
A61K48/00;C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K31/711;A61K38/00;A61P29/00;A61P37/00;A61P37/06;C07K14/725;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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