发明名称 |
AMINO ALCOHOL DERIVATIVE AND METHOD FOR PREPARING THE SAME |
摘要 |
A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y-CH2-C*H(NHP1)-C*H(OH)-R1 (1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2-CH2-C*H(NHP1)-C*H(OH)-R1 (2) (B) leaving P1 from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2-CH2-C*H(NH2)-C*H(OH)-R1 (3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2-CH2-C*H(NHCOR11)-C*H(OH)-R1(4) wherein * represents an asymmetric carbon atom, and P1, R1, R 2 and R" are defined in the specification. A process for preparing alcohol derivatives having an acylamino group through several steps from amino group-protected 2-aminopropanol derivatives, and novel amino alcohols useful as intermediates in the process for preparing the alcohol derivative.
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申请公布号 |
CA2192268(C) |
申请公布日期 |
2009.05.19 |
申请号 |
CA19962192268 |
申请日期 |
1996.12.06 |
申请人 |
SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) |
发明人 |
JINBO, MASAYUKI;OYAMADA, HIDEKAZU;INOKUCHI, JINICHI |
分类号 |
C07D295/13;C07B53/00;C07C215/18;C07C231/02;C07C231/18;C07C233/36;C07C271/20;C07C309/66;C07D207/04;C07D207/08;C07D207/12;C07D211/22;C07D211/44;C07D211/46;C07D241/04;C07D265/30;C07D295/125 |
主分类号 |
C07D295/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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