发明名称 |
Vaccine omfattende en svækket pestvirus |
摘要 |
<p>The present invention relates to attenuated pestivurses, in particular to attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunemodulating activity residing in Npro.The invention also relates to methods for attenuating pestiviruses such as BVDV, nucleic acids encoding said pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV of the invention.</p> |
申请公布号 |
DK1751276(T3) |
申请公布日期 |
2009.05.18 |
申请号 |
DK20050741681T |
申请日期 |
2005.05.18 |
申请人 |
BOEHRINGER INGELHEIM VETMEDICA GMBH |
发明人 |
MEYERS, GREGOR;EGE, ANDREAS;MEYER, CHRISTIANE;VON FREYBURG, MARTINA |
分类号 |
C12N7/04;A61K39/00;A61K39/12;A61K39/187 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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