TRANSDERMALES ARZNEISTOFFVERABREICHUNGSSYTEM MIT BESCHICHTETEN MIKROVORSPRÜNGEN

摘要

A device for transdermally delivering a pharmacologically active agent, the device comprising: a member having a plurality of stratum corneum-piercing microprotrusions; and a dry coating on the member, the coating, before drying, comprising an aqueous solution of an amount of a pharmacologically active agent, wherein said pharmacologically active agent is sufficiently potent to be therapeutical effective when administered in an amount less than about 1 mg, said agent having aqueous solubility of greater than about 50 mg/ml and said aqueous solution having a viscosity less than about 500 centipoises.