CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY
摘要
Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly (triethyenetetramine/cystamine bisacrylamide) copolymer (poly (TETA/CBA) ). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly (TETA/CBA) -PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
申请公布号
WO2009062084(A2)
申请公布日期
2009.05.14
申请号
WO2008US82869
申请日期
2008.11.07
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;YOCKMAN, JAMES, W.;BRUMBACH, JONATHAN;CHRISTENSEN, LANE, V.;KIM, SUNG, WAN
发明人
YOCKMAN, JAMES, W.;BRUMBACH, JONATHAN;CHRISTENSEN, LANE, V.;KIM, SUNG, WAN