USE OF OLIGONUCLEOTIDES WITH MODIFIED BASES AS ANTIVIRAL AGENTS
摘要
<p>1The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.</p>
申请公布号
WO2009060122(A2)
申请公布日期
2009.05.14
申请号
WO2008FI50633
申请日期
2008.11.05
申请人
BALTIC TECHNOLOGY DEVELOPMENT, LTD.;SAARMA, MART;MERITS, ANDRES;KARELSON, MATI