发明名称 |
P38 MAP KINASE INHIBITORS |
摘要 |
<p>Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: formula (I) wherein: G is -N= or -CH=; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5 - 13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2)z-X1-L1 -Y-NH-CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5 - 13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid.</p> |
申请公布号 |
WO2009060160(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
WO2007GB04259 |
申请日期 |
2007.11.07 |
申请人 |
CHROMA THERAPEUTICS LTD.;MOFFAT, DAVID, FESTUS, CHARLES;PINTAT, STEPHANE;DAVIES, STEPHEN |
发明人 |
MOFFAT, DAVID, FESTUS, CHARLES;PINTAT, STEPHANE;DAVIES, STEPHEN |
分类号 |
C07D213/73;A61K31/4412;A61P37/00;C07D409/04 |
主分类号 |
C07D213/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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