SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY
摘要
<p>Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA- containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG- lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.</p>
申请公布号
WO2009061515(A1)
申请公布日期
2009.05.14
申请号
WO2008US12660
申请日期
2008.11.10
申请人
NORTHEASTERN UNIVERSITY;KO, YOUNG, TAG;KALE, AMIT;TORCHILIN, VLADIMIR, P.