摘要 |
<p>Enteric coated capsules or tablets for oral delivery of a protein, polypeptide or peptide drug, in particular for oral delivery of insulin, are provided, comprising microparticles of the protein, polypeptide or peptide drug, microparticles of a protease inhibitor and, optionally, microparticles of an absorption enhancer. The protease inhibitor and the absorption enhancer may be together in the same microparticles. The microparticles of each component are embedded in an enteric polymer matrix. The enteric coated tablet or capsule of the invention enables fast release of the protein, polypeptide or peptide drug at different times at desired loci in the gastrointestinal tract</p> |
申请人 |
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD;SHIMONI, EYAL;RAMON, ORY;KOPELMAN, ISAIAH J.;MIZRAHI, SHIMON;SALZMAN, NIR;NAHMIAS, YAAKOV;OREN, AHARON |
发明人 |
SHIMONI, EYAL;RAMON, ORY;KOPELMAN, ISAIAH J.;MIZRAHI, SHIMON;SALZMAN, NIR;NAHMIAS, YAAKOV;OREN, AHARON |